Uplink™ – FDA Cleared Electrotherapy Device

NEBA® Uplink™ is an FDA-cleared electrotherapy device for treating depression, anxiety, and insomnia. Uplink uses very low current electrical pulses for treating this spectrum of mental health disorders. The device is FDA cleared, available by prescription only, and can be used at home or in a clinician’s office.

To use Uplink™ patients attach standard electrodes just behind the ears, or directly to their ear lobes, and control the amount of current and the duration of stimulation.

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NEBA® Uplink™ is $549. Your initial order covers the Uplink™ device and accessories, shipping and prescription verification.


To complete your order and for us to ship the device your physician needs to document your prescription using the Uplink™ Prescription Form. You can download the form. Follow the instructions on the form to electronically send the prescription to us. If we don’t receive your prescription within 30 days of your initial order, we’ll automatically issue you a refund.


CES devices don’t work for everyone. We get that, so NEBA® Uplink™ comes with a 30-day money back guarantee.  There’s no financial risk to you in trying Uplink.  If Uplink™ doesn’t work for you just give us a heads up by emailing support@nebahealth.com and return the device in the original packaging within 30 days and we will refund your order.  See our return policy, here. No questions asked. Of course, some reasonable terms and conditions apply.  For example, the device can’t be damaged but normal wear and tear is expected.


While the safety data for CES use is robust, clinical effectiveness data is more modest. One recent comprehensive review concluded there is evidence, albeit modest evidence, for CES effectiveness for treating depression and anxiety. See Shekelle (2018). One review team recently concluded that CES acute depression clinical studies could benefit from better design and that none met their criteria subjects be randomly assigned to treatment with either active CES or sham simulated CES. See Kavirajan (2014). One recent clinical study from 2014 found that a CES device using a different frequency from Uplink™ did significantly help patients with anxiety with comorbid depression. See Barkley (2014).

CES clinical efficacy data is modest, but we know that CES affects EEG in ways suggesting some positive underlying physiological impact. Several studies report CES devices like Uplink™ produce changes in the EEG beta region suggesting a positive effect on mental alertness concentration and focus. See, Lee (2019). Also see Fusner (2012). You can find all the studies mentioned here in our CES annotated bibliography.

Finally, many individuals report dramatic symptom improvement though CES therapy. These reports are important to consider even if anecdotal because CES is an orphan technology. Standard CES devices like Uplink™ are simple and non-patentable. There is little likelihood a group would invest in large well-designed clinical studies required to demonstrate effectiveness. See Edelmuth (2010).

A clinical trial of cranial electrotherapy stimulation for anxiety and comorbid depression Benefits and Harms of Cranial Electrical Stimulation for Chronic Painful Conditions, Depression, Anxiety, and Insomnia: A Systematic Review Effects of Cranial Electrotherapy Stimulation on Electrocephalogram

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Frequently asked Questions

Is Uplink™ covered by insurance?

Sometimes. Even though clinicians have prescribed CES for over 50 years some insurances still consider electrotherapy experimental. They cite the lack of high quality clinical validation studies. Contact customersupport@nebahealth.net and we’ll help you check your benefits. Also, we can help you file insurance and appeal denials.

How much does Uplink™ cost?


What if Uplink™ doesn’t work for me?

See our return policy, here. If Uplink™ doesn’t work for you within 30 days of receipt, send the device back in the original packaging. Contact customersupport@nebahealth.net and we’ll help you get started on your return. Of course the policy is subject to reasonable restrictions like you can’t destroy the device and send it back for a refund.

Does using Uplink™ hurt?

Sometimes. Users can adjust intensity to the point that they may experience some mild discomfort. The instructions for use recommend lowering the intensity to just below the pain threshold.

At what Age can I use Uplink™?

18 years.

Why do I need a prescription?

To comply with FDA regulations.

To complete your order and for us to ship the device your physician needs to document your prescription using the Uplink™ Prescription Form. You can download the form. Follow the instructions on the form to electronically send the prescription to us. If we don’t receive your prescription within 30 days of your initial order, we’ll automatically issue you a refund.

Where is Uplink™ made?


Is Uplink™ an open source medical device?

Why yes. Yes, it is.

How long has CES been around?

We can trace CES device origins to the beginning of the 20th century. The Soviet Union conducted CES research for anesthesia. The Japanese adopted the technology in the 1960s to help bullet train operators relax between runs. A Texas business person brought CES to the United States in the 1960s as NeuroTone. The NeuroTone device operated at the same amperage and frequency as Uplink™. When FDA began regulating medical devices in the USA in the 1970s, the NeuroTone device became the first FDA cleared CES device. FDA grandfathered CES devices for treatment of depression, anxiety, and insomnia.

How do CES devices work?

CES devices work by applying a low amperage current to the head. Uplink™ uses a 100Hz alternating current at nominally 1mA. But we don’t know the mechanism of action, i.e. how these devices bring about their physiological effects.

Zahgi (2009) states: “[T]he direction of current is constantly changing with AC stimulation […] [C]ranial AC stimulation may function by 1) inducing synchronous changes in brain activity (as indexed by EEG); 2) altering the release of synaptic vesicles (i.e., stimulating neurotransmitter or endorphin release); 3) interrupting ongoing cortical activity by introducing cortical noise; or 4) via secondary effects of peripheral craniospinal nerve stimulation.”

Fusner(2012) proposes: “[…] 100-Hz CES [ed: like Uplink™] causes cortical brain deactivation in midline prefrontal and parietal regions. In addition, 100-Hz stimulation significantly altered connectivity within the DMN [default mode network]. CES thus appears to result in […] cortical deactivation patterns […] associated with stronger alterations in functional connectivity for 100-Hz stimulation. Moreover, cortical deactivation patterns differed from those associated with current intensity, suggesting that cortical deactivation may depend more on frequency than intensity of stimulation.

“[…], the oscillating current from CES may reach the cortex where it may interrupt normal resting state cortical activity, resulting in deactivation. In doing so, CES may alter brain oscillation patterns […]

“In regards to how the current reaches the brain, because this study used earlobe electrodes, the alternating microcurrent may initially stimulate afferent branches of cranial nerves. Stimulation may initially occur at branches of the facial, glossopharyngeal, and/or the vagus nerves that originate near the electrode placement on the earlobe, then are carried to the brainstem, the thalamus, and finally the cortex.”